Comments on: Toward a Comprehensive Framework for Investigating Copper Dyshomeostasis: The Role of His-Tag Modularity and Alternative Expression Systems in Evaluating Dopamine β-Hydroxylase /2023/04/13/zoe-semersky/ Mon, 15 May 2023 15:59:14 +0000 hourly 1 https://wordpress.org/?v=6.9.4 By: Zoë Semersky /2023/04/13/zoe-semersky/#comment-29999 Fri, 21 Apr 2023 21:20:47 +0000 /?p=41182#comment-29999 Hi Isabelle, the temperature played a role in this expression system, but it’s also important to consider that it was in bacteria. The temperature of the human body is about 37C, and altering that in a person would likely have serious negative effects. The decreased norepinephrine production clinically could suggest that DBH concentrations are lower or malfunctioning in some other way (which is where this work is hopefully headed in uncovering). Great thinking!

]]> By: Prof. Claire Eager /2023/04/13/zoe-semersky/#comment-29945 Fri, 21 Apr 2023 18:08:39 +0000 /?p=41182#comment-29945 This is such a compelling poster, Zoë! How did you balance the work of doing the research and representing it in so many visual and written ways? Congratulations!

]]> By: Isabelle Dwyer /2023/04/13/zoe-semersky/#comment-29922 Fri, 21 Apr 2023 16:49:00 +0000 /?p=41182#comment-29922 Do you know why temperature was seen to play such a big role on the expression of DBH-His? If temperature was able to increase the expression of DBH, couldn’t we theoretically translate that to some sort of potential treatment options for AD and PD if they are seen to have a lower DBH concentrations? Also, this is incredibly cool research and so so impressive!!!

]]> By: Zoë Semersky /2023/04/13/zoe-semersky/#comment-29900 Fri, 21 Apr 2023 16:26:11 +0000 /?p=41182#comment-29900 Thank you, Mrs. Agurkis! I like your thinking. Those are definitely areas to consider down the line. I’d say this is still in the very preliminary stages, but exciting nonetheless!

]]> By: Zoë Semersky /2023/04/13/zoe-semersky/#comment-29899 Fri, 21 Apr 2023 16:24:29 +0000 /?p=41182#comment-29899 I appreciate it, Dr. Judge! Glad the visual was useful.

]]> By: Zoë Semersky /2023/04/13/zoe-semersky/#comment-29898 Fri, 21 Apr 2023 16:23:52 +0000 /?p=41182#comment-29898 Thank you, Dr. Pollock!

]]> By: Zoë Semersky /2023/04/13/zoe-semersky/#comment-29897 Fri, 21 Apr 2023 16:23:23 +0000 /?p=41182#comment-29897 Hi Torence,

One of the most challenging parts was troubleshooting experiments that didn’t go according to plan. Although that was the case, I’d say it was also the most fun and rewarding piece! It forced me to consider my approach from different angles creatively.

]]> By: Shelley Judge /2023/04/13/zoe-semersky/#comment-29840 Fri, 21 Apr 2023 14:10:09 +0000 /?p=41182#comment-29840 Great work, Zoe. I’m such a visual person, so I loved the software you used to model your research. You should be so proud.

]]> By: Ann Agurkis /2023/04/13/zoe-semersky/#comment-29819 Fri, 21 Apr 2023 12:59:15 +0000 /?p=41182#comment-29819 This is amazing, though I’m not totally comprehending it all. Has your study lead you to believe a hypothesis regarding how to potentially control for copper or DBH, or temperature regulation to prevent memory loss? Or maybe that’s just way down the line.
Very impressive and important work! Congratulations!

]]> By: Meagen Pollock /2023/04/13/zoe-semersky/#comment-29788 Fri, 21 Apr 2023 11:41:49 +0000 /?p=41182#comment-29788 Your 3D model is awesome! Nice work!

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